610 α-THALASSEMIA SILENT CARRIER WITH HEMOGLOBINS S AND C

How do hemoglobins S and C result in malaria protection?

The search for a link between genetic factors and human diseases is at the core of a modern multibillion-dollar industry. Nevertheless, although the pages of countless high-impact journals are packed every week with data reporting genetic associations for an entire alphabet of diseases, disappointingly few have delivered on the promise to revolutionize treatment. The association between the sic...

Beta-Thalassemia Carrier Detection by NESTROFT

Comparative oxidation of hemoglobins A and S.

The mutant hemoglobin S (HbS) previously was reported to undergo accelerated autooxidation during incubation in vitro. However, subsequent observations have raised the possibility that this might be explained by adventitious association of molecular iron with HbS, rather than reflecting an inherent property of HbS. Using purified HbA and HbS obtained from genotypic HbAS donors, we found that th...

Dermatoglyphs in patients with beta-thalassemia major and their thalassemia carrier parents.

Dermatoglyphs are cutaneous ridges on the fingers, palms, and soles, formed during early intrauterine life. During this period, and only then, genetic and environmental factors can influence their formation. Beta-thalassemia major is an genetic disease. The aim of the present work was to analyze dermatoglyphs traits in subjects with beta-thalassemia major and their thalassemia carrier parents. ...

Identification and quantification of hemoglobins A, F, S, and C by automated chromatography.

The Bio-Rad Variant Hemoglobin Testing System is an automated HPLC analyzer marketed with a Beta-thalassemia Short Program to quantify hemoglobins (Hbs) F and A2 and assist in detecting Hbs A, S, C, D, and E. We evaluated this system to replace several traditional methods for Hb in our hospital laboratory. Analytical performance relevant to quantifying Hbs A, S, C, and F was assessed with blood...